Cannabinoids for Colon Cancer

by | Dec 7, 2020 | Cancer | 0 comments

For decades, medical scientists and other researchers have known cannabis and cannabinoids are helpful in therapy of cancer patients, but more recent studies suggest that cannabinoids may also be effective in preventing cancer in susceptible patients. Although extensive studies are needed to make accurate conclusions, researchers see potential in CBD’s therapeutical value [1].

This article will look into whether CBD or THC has any effect on colorectal cancer and in what ways they can promote the well-being of the patients.


Brief History of THC/CBD and Cancer

For centuries, cannabis has been used as an herbal remedy. It contains powerful chemical compounds called cannabinoids that activate and improve various physiological systems when they react with the body. Unfortunately, the US Drug Enforcement Agency still classifies marijuana as a controlled substance, lessening its availability to the masses for therapeutic relief. Researchers, however, are still interested in the potential of this powerful remedy and are working non-stop on studies to prove its usefulness.

The marijuana plant naturally contains THC and CBD compounds, along with other chemicals, both of which are believed to have therapeutic potential. Comparing the two, THC has a psychoactive effect on the user and can “fog” the brain, while CBD interacts with the endocannabinoid system in a different way without getting you “high.” Both compounds are found in marijuana, with a bigger concentration of THC. In contrast, CBD is predominantly found in hemp with small amounts of THC.

As a result, the non-psychoactive compound – like CBC – has been primarily researched. Due to the drug-related regulations, some scientists are unable to include THC in their studies.

One way they’ve found cannabis helpful is in the remedy of symptoms in cancer patients. It has been found helpful in treating nausea and vomiting related to chemotherapy, it helps in the treatment of neuropathic pain caused by damaged nerves, and it can help improve the appetite, allowing patients to keep themselves nourished and as healthy as possible for upcoming treatments [2].

Cannabinoids can be beneficial to almost every part of the body, but how do they do it? To understand that, we’ll need to talk about the endocannabinoid system and its function in the body.


The Endocannabinoid System

The ECS is responsible for maintaining a constant state of homeostasis in the body and is essential for a healthy body. The ECS performs an incredibly important function because all of our internal systems need to be in equilibrium to work effectively. When any sort of instability is registered, the ECS kicks in and rushes to the location of the issue to stabilize the condition.

There are three primary elements that make up the endocannabinoid system:

  1. Endocannabinoids. The chemical compounds the body naturally produces. These are structurally similar to endocannabinoids, the chemical compounds found in cannabis, and are the key to how cannabis interacts with the endocannabinoid system.

  3. Cannabinoid receptors. Found on the surface of cells throughout the body, endocannabinoids and cannabinoids are both able to attach to receptors allowing them to communicate with a variety of systems inside the body. This communication is what enables the ECS to detect and correct instability.

  5. Enzymes. Proteins that work to break down the cannabinoids and endocannabinoids after they’ve attached themselves to the receptors and after homeostasis has been achieved. Enzymes are there to make sure the cannabinoids do not create an overcorrection once the risk has been effectively corrected.

Since cannabinoids from cannabis plants are so similar to naturally produced compounds in the body, it’s possible for compounds like THC or CBD to attach to the receptors just as endocannabinoids do. CBD, for instance, has the ability to bind to both the CB1 and CB2 receptors, and once it is attached, it acts as a blocker, binding to receptors and dampening their signals.


The ECS and THC

Studies have shown that cannabinoids interact with the ECS in a variety of ways, many depending on which system it needs to target. Cannabinoids first interact with the ECS through the CB1 and CB2 receptors. The CB1 receptor is more specific to the brain and is what causes the intoxicated feeling many get from THC once it attaches itself to that receptor. The CB2 receptor focuses itself mainly on the immune system and its corresponding cells in the body. In short, activating the CB2 cell does not trigger a psychoactive response in the brain, so a person won’t feel intoxicated when that receptor is used.

The research on cannabinoids and colon cancer found that THC was actually interacting with the system via the CB2 receptors, meaning that no psychoactive effects should be felt, yet all the benefits of the cannabinoids will still be received in the body [3].


What Is Colon Cancer?

Colon cancer will first begin in the colon or rectum, which is why it can also be known as rectal cancer if that is where it is first detected. The colon and rectum are included in the large intestine, which is an important part of the digestive system. In fact, the colon is almost 5 feet long and makes up most of the large intestine. There are sections of the colon which include the ascending, transverse, descending, and sigmoid. All of these need to work together in order to provide proper function and nutrition to the body.

Usually, cancer in the colon is first detected in the form of polyps on the inner lining on the colon or rectum. While there are different types of polyps, and not all become cancer, many do, so it’s important to test and monitor them. The size of the polyp and the number of total polyps are also an indication of whether or not they are cancerous or have a higher risk of becoming cancerous.

If the polyps are left untreated and cancer forms, it can quickly spread into the wall of the colon or rectum. The wall of the colon is made up of many different layers, and while cancer will originally spread to only the innermost layer, it doesn’t take much time for it to spread to every layer, making it much more difficult to treat. After cancer has infiltrated these layers, it has an even higher probability of then growing into blood vessels or nearby lymph vessels, which have the ability to transfer cancer to lymph nodes and ultimately to every part of the body if undetected.

Cancer is known to move quietly and quickly, which is why frequent check-ups are so important, especially for those who are already at higher risk. But with a disease that has the ability to silently invade, how can cannabinoids help?


THC and CBD for Colon Cancer

A recent study [4] on mice has concluded that injecting cannabinoids into the body may have the potential to prevent colon cancers. In order to test this, researchers injected mice with a carcinogen that is known to induce color cancer. At the same time, some of the mice were also given an injection of THC, a powerful and well-known cannabinoid that comes from marijuana plant.


The Results

The mice who were injected with the THC actually lost a substantial amount of weight; however, colon tumors were never detected. In fact, the mice injected with THC also had lower colon inflammation rates due in part to the anti-inflammatory properties of THC. The study showed that THC not only prevented inflammation in the colon, but it also inhibited the growth of colon cancer cells in the body, leading researchers to believe that colon inflammation and cancer are closely related. They concluded that patients at higher risk of developing colon cancer would benefit greatly from the addition of THC or CBD to their daily lives [5].


Inflammatory Bowel Diseases

Patients suffering from IBDs such as Crohn’s disease or ulcerative colitis already struggle with dangerous bowel inflammation in their gastrointestinal tract. These same patients are also at a much higher risk of developing colorectal cancer. This new research could not only help IBD patients deal with their chronic disease, but it could also hold the key to helping them manage it long-term while also protecting themselves from one of the worst possible side effects.

The rates of inflammatory bowel diseases are increasing worldwide, which means the rate of colon and rectal cancers is also rising and will continue to rise. If cannabinoids are going to be important to the treatment and prevention of these diseases, it’s important for the research to continue.



Just like all other research and studies focused on cannabis and cannabinoids, there is still a long way to go before scientists get all the answers they are looking for. However, the current research suggesting how crucial cannabinoids could be to colon cancer prevention is a huge step forward in both cannabis research and cancer research.

Finding any compound that has the potential to prevent cancer is incredibly important to millions of people around the world, and finding one that is natural and easy to use with little to no side effects has the potential to be life-changing. More research is obviously required, but we are on a good path to opening up the possibilities of cannabis and its effect on our health and well-being.


FAQs about THC and CBD For Cancer


How to use CBD oil for colon cancer?

Being a great public health problem, patients who suffer from colon cancer tend to take CBD oil to help them promote well-being. Pure CBD may reduce cell proliferation [6], but there is still more research needed to make any claims.

Taking CBD oil is effortless since you only need to squeeze a few drops under your tongue and hold it for 60 seconds before swallowing. The substance quickly absorbs and takes effect in about an hour or so.


Is there the best CBD oil for cancer?

There is not enough research on CBD oil and cancer, thus, a lack of evidence makes it impossible to claim which CBD oil is the best. What we do know is that if you want to purchase CBD oil, you need to find a reliable and reputable seller, like Mojave, where the product description equals what is inside the bottle.


How much CBD should I take?

To answer this question, you need to take a few factors into consideration. Firstly, it depends on what type of CBD product you have: tinctures, gummies, roll-ons, or salves. Secondly, you should check the concentration of CBD in the product. For example, in Mojave’s CBD Gummies, there is 25mg of CBD per dose. Thirdly, the CBD dosage is calculated based on the weight and the severity of the condition.

The golden rule is to start with a small dosage and then gradually increase it until you feel the desired effect.



The statements expressed on this website are purely opinions of the author and not factual. These statements have not been evaluated by the Food and Drug Administration. Any products referenced on this website are not intended to diagnose, treat, cure, or prevent any disease. It’s highly suggested to consult with your medical professional prior to any use of the products referenced on this website. This website and the author specifically disclaim any liability in connection with the products contained on the website.


Michael Lagnese

Michael Lagnese is the co-founder and CEO of Mojave Rx - a consumer-focused CBD brand specializing in creating high potency products to support athletic performance, physical rehabilitation, and muscle recovery. Outside of his professional endeavors, Michael is also passionate about his personal growth journey. Exercise, meditation, reading, journaling, and continued education are all of the utmost importance and, in his opinion, the key to becoming a more effective leader. Above all, Michael is passionate about making a positive difference in people’s lives, and through Mojave Rx and their top-quality products, he hopes to continue on this journey for many years to come.